For those of us in the bioinformatics and genomics space, the advent of NoSQL databases offer multiple opportunities for storing “Big Data”. However, many of us are still grappling with the same set of questions: when (if ever) does it make sense to switch over to NoSQL? how much data does one need to justify a migration to NoSQL? what types of genomic data sets and applications are ripe for NoSQL? and, given the hundreds of NoSQL databases which now exist (see nosql-database.org), which do you go with?